A few days ago, the International Science and Technology Cooperation Project of the Ministry of Science and Technology, undertaken by Xiamen University, passed the acceptance test for the discovery of microbial innovative drugs using gene cloning and recombination technology, and has applied for two invention patents.
According to reports, Xiamen University and the University of Saarland, Germany, established a separation and identification of myxobacteria and biological activity screening methods, breaking the technical bottleneck difficult to separate and purify myxobacteria and cultivation, the establishment of a library of more than 500 strains of myxomycetes Kind library. At the same time, recombinant expression plasmids for the biosynthetic gene clusters of myxobacteria and S-active compounds were constructed using recombinant engineering techniques, and heterologous expression was achieved in Myxococcus xanthus and Pseudomonas putida. The project also introduced the high-performance liquid chromatography-mass spectrometry technology established by Germany to improve the efficiency of discovering new compounds from secondary metabolites of myxomycetes.
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