Chinese Academy of Sciences research project "precise isothermal titration microcalorimeter" was accepted

【China Instrument Network Instrument Development】 Recently, the Institute of Condition Protection and Finance of the Chinese Academy of Sciences organized an expert at the Institute of Chemical Research, Wang Yilin, to carry out a research project for the research and development of Chinese Academy of Sciences equipment. It is a precision isothermal titration microcalorimeter that simultaneously studies the secondary structure and aggregation behavior of biological macromolecules. "Conclusion acceptance.

The project has developed a precision isothermal titration calorimeter that simultaneously studies the secondary structure and aggregation behavior of biological macromolecules. It has designed and built a constant temperature system, a thermal measurement system, a visible-ultraviolet spectrum measurement system, a Raman spectrum measurement system, and data acquisition. And control system.

The device can perform spectroscopic measurement during the thermal titration. The titration heat and spectrum are both measured by the sample-reference cell dual-channel measurement. A new method for the simultaneous measurement of heat and spectroscopy is established, and the molecules in the process of the aggregation of the biomacromolecule system are successfully realized. The simultaneous acquisition of micro-structures and the interaction between the micro-structures provides new means for the study of macromolecules.

On the basis of the on-site operation and technical testing of the inspection equipment, the acceptance expert group heard work reports, user use reports, and financial review reports of the project team, and reviewed relevant file files. After careful deliberation and full discussion, it was agreed that the project had completed its research and development tasks, reached the expected goals, and agreed to pass the acceptance check.

(Original Title: "The Precision Isothermal Titration Microcalorimeter for Simultaneously Studying the Secondary Structure and Aggregation Behavior of Biological Macromolecules" of the Scientific Research Equipment Development Project of the Chinese Academy of Sciences Passes Acceptance